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Metab Brain Dis 29(1):1936 Kubera M, Obuchowicz E, Goehler L, Brzeszcz J, Maes M (2011) In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression

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By inhibiting this interaction, FOXO4-DRI allows reactivation of the apoptotic pathway in non-proliferative senescent cells, leading to their selective elimination without damaging healthy tissue